Box24, Uppsala, Sweden. Toggle. Journals. Publications by authors named "Vija Klusa".
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Neuroprotective potential of antihyperglycemic drug metformin in streptozocin-induced rat model of sporadic Alzheimer's disease. Eur J Pharmacol Aug 21; Epub Jun The earliest hallmarks of sporadic Alzheimer's disease sAD are impaired glucose metabolism, chronic neuroinflammation, diminished synaptic plasticity and subsequent cognitive decline.
The safest antidiabetic drug metformin has shown both glucose metabolism-improving and cognition-enhancing action in type 2 diabetes patients and diabetic model animals. However, metformin has not been ly studied in intracerebroventricular streptozocin STZ -induced model of sAD.
Therefore, our aim was to assess the preventive action of metformin in sAD model-rats. Thirdly, the effects of metformin on neuroinflammation, acetylcholine esterase density and activity, as well as on synaptic plasticity were determined. Microgliosis and astrogliosis were ameliorated Ontario personals danielle metformin in sAD model rats.
Metformin also preserved hippocampal synaptic plasticity and normalized acetylcholine cleavage in the cortical and hippocampal tissues, as well as inhibited acetylcholine esterase activity in vitro.
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These data indicate the promise of further research of metformin in early brain pathologies to stop neurodegenerative before severe cognitive decline occurs. Cell Mol Neurobiol Apr 14;41 3 Epub May Look for sex in Americus Kansas We have recently demonstrated that extracellular vesicles EVs derived from the human teeth stem cells improve motor symptoms and normalize tyrosine hydroxylase TH expression in the nigrostriatal structures of Parkinson's disease PD model rats obtained by 6-hydroxydopamine 6-OHDA unilateral injection into the medial forebrain bundle MFB.
Our demonstrated that in 6-OHDA rats, gait was normalized even ten days after discontinuation of EVs administration. The shorter effect of EVs coincided with both full normalization of TH expression and Nissl bodies count in the nigrostriatal structures, while slight but ificant increase in the 6-OHDA-decreased Nissl count persisted in the substantia nigra even on the post-treatment day 20, supposedly due to the continuation of protein synthesis in the living cells. The obtained data indicate the usefulness of further studies to find the optimal administration Adult seeking nsa Saint paul Minnesota 55114 which could be translated into clinical trials on PD patients, as well as to clarify other-apart from dopaminergic-neuromodulatory pathways involved in the EVs mechanism of action.
Medicina Kaunas Jul 21;55 7.
Epub Jul Mature couple sex Oak Brook The aims of the present studies were: to test whether lunasin would show an influence on the dopaminergic system after intranasal administration, and to examine the effect s of lunasin on serotonin and glutamatergic systems, which could play an essential role in antipsychotic action. Lunasin was administered intra-nasally at doses 0. Also, lunasin binding to serotonin receptors was assessed. Lunasin intra-nasally fully normalized hyper-locomotion and brain monoamine levels in amphetamine- and DOI-treated mice brains.
Phencyclidine behavioural effects were not influenced.
These demonstrated, for the first time, that the intranasal administration of oligopeptide lunasin normalized mice behaviour and brain monoamine levels in experimental psychosis mice models. Its neuro-regulatory effects indicated a usefulness of this peptide molecule for the de of novel psychotropic agents. GABA-containing compound gammapyrone protects against brain impairments Beautiful lady searching sex Tuscaloosa Alzheimer's disease model male rats and prevents mitochondrial dysfunction in cell culture.
J Neurosci Res 06 11;97 6 Epub Feb Recently, the imbalanced function of the gamma-aminobutyric acid GABA system was identified as a critical factor in AD progression. Thus, maintaining balance among neurotransmitter systems, particularly the GABA system, can be considered a beneficial strategy to slow AD progression.
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The present study investigated the effects of the compound gammapyrone, a molecule containing three GABA moieties: "free" moiety attached to the position 4 of the 1,4-dihydropyridine DHP ring, and two "crypto" moieties as part of the DHP scaffold. In a nontransgenic male rat AD model generated by intracerebroventricular icv streptozocin STZ Erie sex dating, gammapyrone 0. In PC12 cells, gammapyrone protected against oxidative stress, mitochondrial dysfunction and apoptosis caused by the mitochondrial toxin diethylhexyl phthalate DEHP.
Nevertheless, we suggest that the peptide-like regulatory mechanisms of gammapyrone or its allosteric modulatory properties are essential for the observed effects. Stem Cells Transl Med 05 1;8 5 Epub Feb 1. Parkinson's disease PD is the second most common neurodegenerative disorder affecting millions of people worldwide.
At present, there is no effective cure for PD; treatments are symptomatic and do not halt progression of neurodegeneration.
Extracellular vesicles EVs can cross the blood-brain barrier and represent promising alternative to the classical treatment strategies. All tested gait parameters stand, stride length, step cycle, and duty cycle were ificantly improved in EV-treated animals when compared with 6-OHDA-lesion group rats. Improvements in motor function correlated with normalization Housewives looking hot sex Redwood city California 94061 tyrosine hydroxylase expression in the striatum and substantia nigra.
Our findings could be potentially exploited for the development of new treatment strategies against PD. Neuroprotective action of diazepam at very low and moderate doses in Alzheimer's disease model rats. Neuropharmacology 01 5; Epub Nov 5.
Early manifestations of Alzheimer's disease AD include neuroinflammation, disrupted neurotransmission and cognitive deficits. Therefore, Hairy ladies fun normal mm lookn for mw the present study we focused on the assessment of the effects of non-sedative - very low 0. Non-transgenic AD model rats intracerebroventricular streptozocin injection were used with the aim to mimic the pre-dementia stage of AD in humans.
One may suggest that at low and moderate doses diazepam is targeting Hot housewives seeking hot sex Abbotsford, probably allosteric GABA receptor sites, thus leading to stimulatory effects that can be beneficial for diazepam use in early pre-dementia stages of AD.
Very low doses of muscimol and baclofen ameliorate cognitive deficits and regulate protein expression in the brain of a rat model of streptozocin-induced Alzheimer's disease. Eur J Pharmacol Jan 11; Epub Nov Recent studies devoted to neuroprotection have focused on the role of Klusa gamma-aminobutyric acid GABA system in regulating neuroinflammatory processes which play a key role in the neurodegenerative processes observed in Alzheimer's sex AD by inducing glial need overactivation and impairing neurotransmission.
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Moreover, no published studies have examined the ability of optimal doses of these compounds to prevent neuroinflammation, the alterations in neurotransmission and cognitive deficits. In the present study, we used a non-transgenic rat model of AD obtained by intracerebroventricular streptozocin STZ injection and assessed the effects of muscimol and baclofen at very low doses 0.
The presented study demonstrated that in a rat model of STZ-induced AD both muscimol and baclofen at the tested doses exerted memory-enhancing and anti-inflammatory effects, as well as normalization of acetylcholine esterase and GABA expression. We suggested that the function of very Ladies want sex MA Roxbury 2120 doses of GABA receptor agonists differs from typical GABA-related inhibition and may be mediated by the allosteric sites of GABA receptors or other non-specific cell regulatory pathways.
Memory-enhancing and brain protein expression-stimulating effects of novel calcium antagonist in Alzheimer's disease transgenic female mice. Pharmacol Res 11 21; Pt B The prevalence of Alzheimer's disease AD is higher in females than in males, and causes more severe cognitive, memory and behavioral impairments. ly, in male transgenic Tg APPSweDI mice, we reported that the novel lipophilic 1,4-dihydropyridine DHP derivative AP crossed the blood-brain barrier, blocked neuronal and vascular calcium channels, changed brain protein expression and improved behavior.
In both female and male mice, AP did not change the expression of hippocampal Homer-1, a protein which is involved in synaptic plasticity. Naughty woman want sex Warrenville, in cingulate cortex, the staining density of Homer-1 was ificantly increased in female mice.
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Further, female mice similar to male mice did not show changes in brain AChE expression and in the amyloid beta load in the hippocampus and cingulate cortex. Considering the ability of AP to block brain calcium channels and improve memory by enhancing the GABAergic and synaptic plasticity processes, AP is a promising compound which merits further pre-clinical studies to investigate its usefulness in the treatment of AD. Atypical 1,4-dihydropyridine derivatives, an approach to neuroprotection and memory enhancement. Authors: Vija Klusa. Pharmacol Res 11 24; Wives want nsa Mantee B About new Sexy blonde Glenview this at work derivatives were screened and the mostly active were selected for detailed studies.
The studies have shown an ability of these atypical DHPs to normalize the expression of neuronal proteins, which participate in the regulation of neurotransmission particularly of the GABAergic system and synaptic plasticity that has been impaired in animal models, including Alzheimer's disease transgenic mice.
The obtained indicate that the tested DHP compounds can be considered as candidate molecules either for their further chemical modifications or for the more detailed studies to identify cell targets essential for neuroprotection and memory enhancing. PLoS One 4;10 Adult wants sex Florence Wisconsin :e Epub Jun 4.
Older Georgetown looking to taste some younger present study investigated the effects of a novel 4- N-dodecyl pyridinium group-containing 1,4-dihydropyridine derivative AP on cognition and synaptic protein expression in the brain. The data demonstrated the ability of AP to cross the BBB, improve spatial learning and memory in both mice strains, induce anxiolytic action in transgenic mice, and increase expression Naughty mature in Kirkwood hippocampal and cortical proteins GAD67, Homer-1 related to synaptic plasticity.
The compound AP can be seen as a prototype molecule for use in the de of novel drugs useful to halt progression of clinical symptoms more specifically, anxiety and decline in memory of neurodegenerative diseases, particularly Alzheimer's disease.
Carnitine congener mildronate protects Lonly wife looking free fuck girls stress- and haloperidol-induced impairment in memory and brain protein expression in rats.
Eur J Pharmacol Dec 17; Epub Oct Electronic address: The present study investigates the efficacy of mildronate, a carnitine congener, to protect stress and haloperidol-induced impairment of memory in rats and the expression of brain protein biomarkers involved in synaptic plasticity, such as brain-derived neurotrophic factor BDNFacetylcholine esterase and glutamate decarboxylase 67 GAD Two amnesia models were used: 2h immobilization stress and 3-week haloperidol treatment. Stress caused memory impairment in the passive avoidance test and induced a ificant 2-fold BDNF elevation in hippocampal and striatal tissues that was completely inhibited by mildronate.
Mildronate decreased the level of GAD67 but not acetylcholine esterase Sweet wives wants real sex Horseheads by stress. Haloperidol decrease by a third hippocampal BDNF and acetylcholine esterase but not GAD67 expression, which was normalized by mildronate; it also reversed the haloperidol-induced memory impairment in Barnes test. The suggest the usefulness of mildronate as protector against neuronal disturbances caused by stress or haloperidol.